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CAR T cell therapy receives approval for use across European Union
car t flash mob

The Abramson Cancer Center celebrates Kymriah’s initial approval by the U.S. Food and Drug Administration in August 2017 with a flash mob.

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CAR T cell therapy receives approval for use across European Union

The European Commission has approved a personalized cellular therapy developed at the Abramson Cancer Center, making it the first CAR T cell therapy permitted for use in the European Union in two distinct indications.

Penn Today Staff

Penn Medicine’s Carl June receives 2018 Albany Prize
june

Penn Medicine’s Carl June receives 2018 Albany Prize

Carl June, a gene therapy pioneer at the Abramson Cancer Center, will receive the 2018 Albany Medical Center Prize in Medicine and Biomedical Research.

Penn Today Staff

Drugs in development for cancer may also fight brain diseases, including ALS
In cells under duress, stress granules (in magenta) form outside of the nucleus (in blue). TDP-43 protein in green (arrow) that cannot bind to PolyADP ribose (PAR) builds up in large clumps distinct from stress granules. (Image: Leeanne McGurk, University of Pennsylvania; Molecular Cell)

In cells under duress, stress granules (in magenta) form outside of the nucleus (in blue). TDP-43 protein in green (arrow) that cannot bind to PolyADP ribose (PAR) builds up in large clumps distinct from stress granules. (Image: Leeanne McGurk, University of Pennsylvania; Molecular Cell)

Drugs in development for cancer may also fight brain diseases, including ALS

In a study done by researchers at the Perelman School of Medicine and the School of Arts and Sciences, PARP inhibitors, which are used for fighting cancer, can be useful for the treatment and prevention of brain disorders such as ALS.

Karen Kreeger

Cancer cells send out ‘drones’ to battle the immune system from afar
Guo cancer drones

Like drones heading for battle, cancer cells emit vesicles containing immunity-suppressing proteins to tamp down T cell responses at sites throughout the body. (Image: Kelsey Burke)

Cancer cells send out ‘drones’ to battle the immune system from afar

Checkpoint inhibitor therapies have made metastatic melanoma and other cancers a survivable condition, but only for some patients. Researchers uncovered a novel mechanism by which tumors suppress the immune system, raising the possibility that a straightforward blood test could predict which patients could respond to immunotherapy.

Karen Kreeger , Katherine Unger Baillie

Hyperbaric oxygen: The mysterious therapy that saved a cancer survivor from radiation side effects

Hyperbaric oxygen: The mysterious therapy that saved a cancer survivor from radiation side effects

Hyperbaric therapy is controversial, according to Matthew Kelly of HUP, largely because “it’s expensive, and some practitioners overuse it, which gives a black eye to the field.” However, for some patients, the oxygen-rich environment can promote healing and fight infection.

Therapy for rare cancers receives FDA approval
microscope

Therapy for rare cancers receives FDA approval

A trial led by researchers at the Abramson Cancer Center received first approval for AZEDRA, an anti-cancer drug for advanced pheochromocytoma and paraganglioma patients who are not candidates for surgery.

Penn Today Staff