Cancer Research

Study finds mutation driving deadly brain tumors, and a potential remedy

Researchers at Penn and the Ludwig Institute for Cancer Research discovered that a mutation in the epidermal growth receptor gene indicates a severe glioblastoma, and targeting this particular gene may further treatment.

Study reveals secrets of ‘hot’ and ‘cold’ pancreatic cancer tumors

Immune cell makeup of tumors, and their ability to metastasize, is controlled by factors specific to individual cancer cells themselves.

Penn Makes Third Big Biotech Bet, Helping to Raise $53M for Carisma

Cancer-fighting biotech company Carisma Therapeutics Inc. is the latest addition to Penn’s recently-announced investment plan. Roy Rosin, CIO at Penn Medicine, said, “Penn’s commitment is pretty exciting for this region.”

New DVM Meghan Ramos continues her dog scent detection research as a Penn Vet Working Dog Center fellow.

At Penn Vet's Working Dog Center, Ramos is leading research projects training dogs to detect infections using scent detection.

How baking soda may boost cancer therapy

Researchers describe how acidity makes oxygen-starved cancer cells dormant and drug resistant, and efforts to reduce acidity may be the key to improved responses to immunotherapy.

Researchers Use Immune-Cell ‘Army’ to Battle Another Tough Cancer

Carl June of the Perelman School of Medicine responded to news of tumor-infiltrating lymphocytes’ success in treating breast cancer, calling the results “striking.” He wondered, however, if this was “one in a million … or something that is an approach that will benefit many women?”

A Single Cell Spurs 5-Year Remission for Penn Leukemia Patient

The Perelman School of Medicine’s J. Joseph Melenhorst authored a study on the effects of CAR T cells on the treatment of chronic lymphocytic leukemia. Since receiving the modified T cells, the patient has been cancer-free for five years.

Mathematical model explains why metastasis can occur even when cancer is caught early

Researchers are uncovering the unique nature of individual cancer "communities" and how they evolve, and applying math models to understand their growth.

Surgeon’s hands put together a puzzle depicting a pancreas with surgical tools.

Ovarian cancer drug shows promise in pancreatic cancer patients

Researchers at the Perelman School of Medicine have isolated the specific mutations that respond to FDA-approved treatments for ovarian cancer, opening up treatment options for other cancer patients who harbor those mutations.

Different diseases elicit distinct sets of exhausted T cells

A new study by researchers at the Perelman School of Medicine found that immune systems that are battling long-term infections or chronic diseases are left fatigued, and identified nine distinct varieties of exhausted T cells, or Tex.

Filters