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Novel coupled nanopore platform offers greater precision for detecting molecules
Artist depiction of DNA moving through a nanopore system.

Marija Drndić of the School of Arts & Sciences and Dimitri Monos of the Perelman School of Medicine and Children’s Hospital of Philadelphia led a team of researchers who developed a new nanostructure platform that allows for more precise detection and control of biomolecules, such as DNA and proteins. This exciting new platform signals a new era of synthetic biology, paving the way for enhanced DNA sequencing and protein conformation detection.

(Image: Courtesy of artist) 

Novel coupled nanopore platform offers greater precision for detecting molecules

An interdisciplinary team of researchers from Penn have created the first ever reusable coupled nanopore platform for detecting and guiding molecules, findings could pave the way for much improved DNA sequencing and molecule identification.
New biomarkers can help target treatment for chronic skin disease
Microscopic view of granulomatous tissue.

Cellular view of granulomatous tissue.

(Image: iStock/Md Saiful Islam Khan)

New biomarkers can help target treatment for chronic skin disease

Researchers at Penn Medicine have found a pathway in certain lymphoid cells that, once targeted, inhibit granulomas from forming in patients with sarcoidosis.

Alex Gardner

Gene therapy trial sees massive improvement in vision
Closeup view of an eyeball with a vision test graphic.

Image: iStock/murat4art

Gene therapy trial sees massive improvement in vision

Patients with a rare disease affecting their sight have experienced quick vision improvements that sustained for the full yearlong Penn Medicine study, with some experiencing a 10,000-fold improvement in their vision.
Weight management drug does not increase risk of depression or suicidal behavior
A person opening the top of a semaglutide prescription pen.

Image: iStock/imyskin

Weight management drug does not increase risk of depression or suicidal behavior

In new clinical trials, researchers from Penn Medicine find that for people without known major psychopathology, taking semaglutide for weight loss are at no increased risk of mental health issues.

From Penn Medicine News

Keeping calm in case of catastrophe
A group of Penn Medicine emergency responders with face masks look over plans during an emergency drill.

Emergency medicine staff get a training over breakfast on how to care for victims of an explosion.

(Image: Courtesy of Penn Medicine News)

Keeping calm in case of catastrophe

How emergency medical teams at Penn Medicine build the playbook for disaster preparedness.

Kelsey Geesler

Understanding the cellular mechanisms driving solid tumors’ robust defense system
A 3D rendering of the tumor microenvironment with cancer cells, T-Cells, nanoparticles, cancer associated fibroblast layer of tumor microenvironment normal cells, molecules, and blood vessels.

In a collaborative interdisciplinary study, Michael Mitchell of the School of Engineering and Applied Science, Wei Guo of the School of Arts & Sciences, and Drew Weissman of the Perelman School of Medicine show that solid tumors can block drug-delivery mechanisms with a “forcefield-like” effect but certain genetic elements that can effectively “shut down” the forcefield. Their findings hint at new targets for delivering cancer treatments that use the body’s immune system to fight tumors.

(Image: iStock / CIPhotos)

Understanding the cellular mechanisms driving solid tumors’ robust defense system

Researchers from Penn have identified a “forcefield-like” defense system in solid tumors and the genetic elements that can switch it off.
Uncovering new antibiotics inside the human gut
Microscopic rendering of bacterial in the small intestines.

Image: iStock/ChrisChrisW

Uncovering new antibiotics inside the human gut

Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.

Ian Scheffler

Penn Medicine, 76ers restore community basketball court
Members of the Penn Medicine community play basketball with kids at the Roberto Clemente Park.

The updated Roberto Clemente Park in Fairmount now boasts a freshly repaved court complete with new backboards and nets.

(Image: Courtesy of Penn Medicine News)

Penn Medicine, 76ers restore community basketball court

The latest product of the partnership between two iconic Philadelphia institutions, a newly refurbished court at Roberto Clemente Park will support healthy behavior in the community.

From Penn Medicine News