How mismanagement of gout could have impacted the American Revolution Coloured etching by T.L. Busby, 1826.nocred How mismanagement of gout could have impacted the American Revolution Penn biology professor Philip A. Rea has written a provocative piece examining how gout sidelined two influential 18th-century British leaders and why England eschewed an effective gout treatment. 2 min. read
Penn Nursing releases open-source blueprint to help institutions worldwide launch nurse-led innovation accelerators Penn Nursing releases open-source blueprint to help institutions worldwide launch nurse-led innovation accelerators Penn Nursing has released a comprehensive guide for institutions to nurse-led innovation accelerators, or structured pathways to bring nurse-led ideas to fruition.
Ménière’s disease may begin early in inner ear development Image: Leonello Calvetti via Getty Images Ménière’s disease may begin early in inner ear development A Penn Medicine study shows the first clear biological roadmap for a poorly understood inner ear disorder. 2 min. read
A specialized approach to mental health crisis care at HUP–Cedar Stephanie Hollister (right) is the assistant vice president of behavioral health for the Cedar Avenue Crisis Response Center.(Image: Courtesy of Penn Medicine News) A specialized approach to mental health crisis care at HUP–Cedar Penn’s Southwest Philadelphia crisis response center has expanded access, eased emergency department crowding, and connected more patients to ongoing mental health support. 2 min. read
Immune activation may determine success of dual-target CAR T therapy in glioblastoma Image: iStock/DedMityay Immune activation may determine success of dual-target CAR T therapy in glioblastoma New research from Penn Medicine finds that activation of natural killer cells is linked to longer survival, and suppressive immune cells is tied to poor response. 2 min. read
Novel medicine for rare disease prompts $10M gift for trials Novel medicine for rare disease prompts $10M gift for trials The Clayco Foundation award to Penn Medicine will go toward safety trials of a new small molecule drug aimed at treating RVCL, a rare, fatal disease with no cure.
Driving harm reduction Driving harm reduction Penn Nursing’s Harm Reduction working group has mobilized to write policy briefs about pressing issues related to harm reduction, and made connections to those tracking relevant policy at the local and state levels.
The history of Pennsylvania Hospital’s Pine Building nocred The history of Pennsylvania Hospital’s Pine Building The original structure of the nation’s first chartered hospital—home to early mental health and maternity care—is a living symbol of innovation. 3 min. read
AI framework aids target discovery for CAR T cell therapy Image: Yuuji via Getty Images AI framework aids target discovery for CAR T cell therapy Researchers at Penn Medicine have created a generalizable strategy to identify new targets for CAR T cell therapy. 2 min. read
CAR T cell therapy leads to 10-year remissions in B-cell lymphoma patients Image: Kateryna Kon/Science Photo Library via Getty Images CAR T cell therapy leads to 10-year remissions in B-cell lymphoma patients A long-term follow-up from one of the earliest CAR T cell therapy clinical trials shows potential cures in more than one-third of patients treated at Penn Medicine. 2 min. read