Immunology

One protein’s role in genomic intermingling and T cell development

The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions.

The many uses of CRISPR: Scientists tell all

Carl June and Ed Stadtmauer comment on the last decade’s revolution in the treatment of diseases.

T cells labeled in fluorescent green patrol the vascular system, labeled in red

Regulating the regulators of the immune system

Research led by School of Veterinary Medicine scientists reveals a new layer of complexity with which the immune system finds a balance between controlling pathogens and protecting healthy tissue.

A decade of CAR T cell therapy

In a feature on the history and future of CAR T, the work of Carl June, Michael C. Milone, Aimee Payne, Drew Weissman, and Jonathan Epstein from the Perelman School of Medicine is highlighted.

CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue

New research finds that CAR T cells can eliminate solid tumors, but do not damage healthy, normal tissues that also express a tumor antigen, because the tumor antigen is sequestered and hidden between the normal cells.

Two people stand closely together, smiling

Decade-long remission after CAR T cell therapy

Two patients represent longest-known CAR T cell response to date, providing insight into treatment effect and outcomes.

Microscopic view of a macrophage devouring a cancer cell.

First-in-human trial with CAR macrophages shows promise targeting solid tumors

A new Penn study demonstrates that engineered macrophages, which can be targeted to tumors, may be a possible new immune-based treatment of some cancers.

Gloved hands holding a pipette over a lab petri dish.

New insights into T-cell exhaustion could improve cancer immunotherapies

A new Penn Medicine study finds that suppressing key exhaustion genes may allow CAR T cell treatments to be used much more effectively against pancreatic and other solid cancers.

Illustration representing T cells attacking cancer cells

A new class of CAR T cells targets previously untargetable cancer drivers

Focusing on neuroblastoma, researchers from the Perelman School of Medicine and Children’s Hospital of Philadelphia have harnessed the immune system to destroy tumors.

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