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Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer
Pancreatic cancer cells.

Image: Nemes Laszlo/Science Photo Library via Getty Images

Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer

Research led by Penn Vet’s Ellen Puré has used lipid nanoparticles to generate CAR T cells directed at a type of tumor support cells—cancer-associated fibroblasts—melting away the protective barrier around pancreatic tumor cells and paving the way for a potentially safer, more accessible, and cost-effective method to treat solid tumors.

3 min. read

Penn GSE organizes transformative leadership professional development in Alabama

Penn GSE organizes transformative leadership professional development in Alabama

As a part of an ongoing Wallace Foundation funded initiative, Penn’s Graduate School of Education (GSE) brought district teams from across the country to Montgomery, Alabama for immersive learning at the Legacy Sites with founder Bryan Stevenson and GSE professor Howard Stevenson.

From Penn GSE

A stiff defense: Rethinking gum disease
A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

(Image: Hardik Makkar)

A stiff defense: Rethinking gum disease

Penn Dental Medicine’s Kyle H. Vining and Hardik Makkar take a biomaterials approach to understanding periodontal disease, using a hydrogel system to investigate how the physical properties of the gum tissue impact inflammation.

3 min. read

Music, friendship, and a podcast on the side
Emily Wilson, Kevin Platt, and Paul St. Amour seated with microphones at Kelly Writers House.

Emily Wilson, Kevin Platt, and Paul St. Amour recording an episode of SideGig at Kelly Writers House.

nocred

Music, friendship, and a podcast on the side

Through their new project, SideGig, School of Arts & Sciences faculty Paul Saint-Amour and Kevin Platt explore songs and sound. Plus, it gives the pals a chance to hang out.

From Omnia

2 min. read

When bone behaves like a sponge
Three members of the Tertuliano lab looking at a computer in the lab.

To visualize the nanoscale structures, the Tertuliano lab often uses large-scale models like the one pictured.

(Image: Sylvia Zhang)

When bone behaves like a sponge

Penn Engineers in the Tertuliano Lab have developed a nanoengineered 3D-printed scaffold for observing how cells feel force.

Melissa Pappas

2 min. read

A topical cream may prevent or slow growth of some common skin cancers

A topical cream may prevent or slow growth of some common skin cancers

An experimental cream developed at Penn Medicine that blocks a specific enzyme may offer a precise, better‑tolerated path to prevent and treat cutaneous squamous cell carcinoma.

Alex Gardner

1 min. read

Will LLMs replace coders? Not entirely

Will LLMs replace coders? Not entirely

After ChatGPT’s launch, the percentage of routine coding questions on an online forum fell sharply, while novel questions rose, according to new research by Wharton’s Neha Sharma.