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By altering bone marrow, ‘training’ can prepare innate immune system for future challenges
Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis

Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis, worked with an international team to show that the innate immune system--typically thought to lack immune memory--can in fact be trained to "remember" past threats.

By altering bone marrow, ‘training’ can prepare innate immune system for future challenges

George Hajishengallis of the School of Dental Medicine and an international team of colleagues have found that “training” the immune system causes changes in the precursors of immune cells in the bone marrow. These changes could facilitate a more robust response to future infections or even enable the immune system to regenerate faster after chemotherapy.

Katherine Unger Baillie

Improving oral cancer diagnosis on many fronts

Improving oral cancer diagnosis on many fronts

A comprehensive dental visit includes more than a cleaning and X-rays; well-trained dentists know they must also take a thorough look inside the oral cavity to spot any potentially unusual lesions that could signal oral cancer.

Katherine Unger Baillie

Targeting enzyme in ‘normal’ cells may impede pancreatic cancer’s spread, Penn Vet team shows

Targeting enzyme in ‘normal’ cells may impede pancreatic cancer’s spread, Penn Vet team shows

Cancer of the pancreas is a deadly disease, with a median survival time of less than six months. Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer’s insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the cancer has almost invariably spread to other organs.

Katherine Unger Baillie

Penn Study Links Mutations in Notch Gene to Role in B Cell Cancers

Penn Study Links Mutations in Notch Gene to Role in B Cell Cancers

Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma. However, the role of Notch in these cancers has been uncertain.

Karen Kreeger

Moonshot Grant Will Help Researchers See Two of Cancer’s Key Food Sources at Once

Moonshot Grant Will Help Researchers See Two of Cancer’s Key Food Sources at Once

Imagine trying to take a picture of a runner, but only being able to see her feet. If you could see her whole body, you’d get the full picture of how she uses both legs to put one foot in front of the other to reach top speed.

John Infanti

FDA approves personalized cellular therapy for advanced leukemia
hand holding bag containing manufactured CAR-T cells

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FDA approves personalized cellular therapy for advanced leukemia

Investigators at the Perelman School of Medicine and CHOP, who together led research, development, and clinical trials of the new therapy in collaboration with Novartis, hail the FDA’s approval as a game changer for the treatment of younger patients battling the aggressive blood cancer and a pivotal milestone in this new era of cellular therapies.